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SCH900776 S-isomer

CAS No. 891494-64-7

SCH900776 S-isomer( MK-8776 S-isomer )

Catalog No. M17644 CAS No. 891494-64-7

SCH900776 (S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	141	In Stock
25MG	250	In Stock
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Biological Information

Product Name

SCH900776 S-isomer
Note

Research use only, not for human use.
Brief Description

SCH900776 (S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).
Description

SCH900776 (S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM).
In Vitro

——
In Vivo

——
Synonyms

MK-8776 S-isomer
Pathway

Others
Target

Other Targets
Recptor

CDK2| Chk1| Chk2
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

891494-64-7
Formula Weight

376.25
Molecular Formula

C15H18BrN7
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL; 265.78 mM
SMILES

Cn1cc(cn1)c1c2nc(c(c(n2nc1)N)Br)[C@H]1CCCNC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Guzi TJ, et al. Mol Y Ther, 2011, 10(4), 591-602.

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